Pietro Pichierri Selected Research

Werner Syndrome (Werner's Syndrome)

1/2022	R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1.
1/2022	SHP2's gain-of-function in Werner syndrome causes childhood disease onset likely resulting from negative genetic interaction.
2/2020	Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability.
1/2019	ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells.
11/2014	Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.
9/2013	Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
9/2012	Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.
3/2011	The Werner syndrome protein: linking the replication checkpoint response to genome stability.
9/2010	ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
10/2008	Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.

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Pietro Pichierri Research Topics

Disease

14	Werner Syndrome (Werner's Syndrome) 01/2022 - 03/2003
11	Neoplasms (Cancer) 01/2021 - 10/2002
9	Genomic Instability 01/2022 - 04/2002
4	Fanconi Anemia (Fanconi's Anemia) 09/2013 - 10/2002
2	Infections 10/2020 - 01/2019
2	Ataxia Telangiectasia (Louis Bar Syndrome) 02/2020 - 09/2013
2	Chromosome Aberrations (Chromosome Abnormalities) 01/2016 - 09/2013
2	Bone Marrow Failure Disorders 09/2013 - 11/2003
2	Hypersensitivity (Allergy) 03/2004 - 11/2003
1	Noonan Syndrome (Female Pseudo-Turner Syndrome) 01/2022
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	Chromosomal Instability (Chromosome Stability) 01/2018
1	Anemia 03/2004
1	Aplastic Anemia (Anemia, Hypoplastic) 03/2004
1	Fanconi Syndrome (Syndrome, Fanconi) 03/2004
1	Colorectal Neoplasms (Colorectal Cancer) 04/2003
1	Ataxia (Dyssynergia) 04/2002
1	Bloom Syndrome 04/2002

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
9	DNA (Deoxyribonucleic Acid)IBA 10/2020 - 04/2002
3	Phosphotransferases (Kinase)IBA 01/2019 - 03/2003
2	ChromatinIBA 02/2020 - 10/2008
1	Protein Tyrosine PhosphatasesIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 02/2020
1	Checkpoint Kinase 1IBA 02/2020
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2020
1	Reverse Transcriptase InhibitorsIBA 01/2020
1	DNA Transposable Elements (Element, IS)IBA 01/2020
1	efavirenz (Sustiva)FDA Link 01/2020
1	2- (sec- butylthio)- 6- (1- (2,6- difluorophenyl)propyl)- 5- methylpyrimidin- 4(3H)- oneIBA 01/2020
1	Sirtuin 1IBA 01/2019
1	Discoidin Domain ReceptorsIBA 01/2019
1	CarcinogensIBA 01/2019
1	Viral ProteinsIBA 01/2019
1	Cruciform DNA (Holliday Junctions)IBA 01/2017
1	Recombinases (Recombinase)IBA 01/2016
1	Exonucleases (3' 5' Exonuclease)IBA 11/2015
1	Werner Syndrome HelicaseIBA 09/2013
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 09/2013
1	DNA-Activated Protein KinaseIBA 09/2013
1	A-Form DNA (A-DNA)IBA 09/2013
1	NSC 617145IBA 09/2013
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 09/2013
1	RecQ HelicasesIBA 09/2012
1	DNA HelicasesIBA 03/2011
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 10/2008
1	EnzymesIBA 10/2008

Therapy/Procedure

2	Therapeutics 01/2021 - 02/2020